RIKEN Brain Science Institute (RIKEN BSI) RIKEN BSI News No. 12 (May. 2001)



RIKEN, Jyokichi Takamine and BSI

Dr. Katsuhiko Mikoshiba
Group Director, Developmental Brain Science Group


At the Institute for Protein Research, Osaka University, I became acquainted with the practical perspectives of scientific research and an academic environment where researchers pursued pragmatic achievements while fostering unique ways of thinking in a free atmosphere. Affected by such a pragmatic environment, I took a post in the Institute of Medical Science at the University of Tokyo.
At the same time, I was asked to join the newly launched research project in neuroscience at the Life Science Tsukuba Research Center, where I was appointed as a chief scientist. In the Tsukuba laboratory, competent researchers, including the chief researcher Yoji Ikawa, engaged in heated discussions day and night, as they aimed to redefine the practice of life science research. Their topics of discussion differed widely, ranging from the overall importance of research in top science to the various ways of approaching issues, developing personnel, and investing in research just to name a few. At the same time in Wako, the Frontier Research System was being established as an epochal Japanese research system and this was where Dr. Masao Ito took his post and later became director. Eager expectations about brain science and the national budget were combined to help launch the RIKEN Brain Science Institute (BSI) in Wako with Dr. Ito appointed as Director. The establishment of the Brain Science Institute was possible because of the great efforts of many individuals, including the former president Minoru Oda who suddenly passed away just recently. Our group also moved to Wako where we started working with the other groups.
In looking back at the ten years that have passed since I joined RIKEN, I realize that one of RIKEN's most admirable qualities is its effective administrative system. Once a decision has been made the administrative system will immediately begin putting into action what has been decided. An administrative system as functional as the one at RIKEN is rarely seen within universities or similar structures. What is more, RIKEN is unafraid of making difficult decisions that may have a decisive impact. For example, when chief scientists are discussing plans, the members may even work toward implementation of those plans even if they may have rather negative implications for members of their own systems. This example succinctly illustrates RIKEN's commitment to policies that focus on eliminating any barriers which may hamper the future development of science. There is consensus that as long as there is confidence about the best path to the future, there is a willingness to go as far as eroding or superseding any short term authority. Even staff members who once took stances opposing the boards of directors can be appointed as directors several years after. This rigorous system that encourages healthy debate is exactly what I admire RIKEN for.
It is therefore not surprising that RIKEN introduced BSI Ñ a new system of a size comparable to itself Ñ an operation where much of the future direction of the institute is developed through meetings by the chief scientists.
Furthermore, no description of RIKEN would be complete without remembering Dr. Jyokichi Takamine. Recently, I had the chance to read a book entitled "The Life of Jyokichi Takamine - Truth in the Discovery of Adrenaline (Asahi sensho)," which was jointly written by Kazumasa Iinuma and Tomio Kanno. The book goes on to describe Dr. Jyokichi Takamine as a scientist who excelled in chemistry and pharmacology and succeeded in sampling Takadiastase and Adrenaline. He initiated what is today called "venture business" by patenting "Takadiastase" as a gastrointestinal drug and "Adrenaline" as a hemostat or vasopressor and gained huge profits from these patents. Adrenaline was the first hormone in the world to be crystallized out. What is more, Dr. Takamine insisted on establishing the "Institute of Physical and Chemical Research (RIKEN)" and contributed greatly to its foundation. He was convinced that in order to develop human resources that were rich in "originality" and implement creative achievements, it was necessary to establish a research institute that was open to the private sector in principal. Accordingly, he suggested setting up the Institute and requested that the nation provide for the cost of expenses, which were almost equivalent to the cost of building a state-of-the-art battleship in those days. This is how the Institute of Physical and Chemical Research was formed. It is true that Dr. Takamine's venture business success was partly due to the competent talents that surrounded him, but it was in larger part due to his own eminent capabilities, such as his competence as an experimental scientist, his deep foresight, his information-gathering ability, and most importantly his ability to effectively combine all of his skills in pursuit of his visions for the future.
Science is triggered by basic questions, but it can be difficult to develop it beyond mere curiosity. Dr. Takamine realized this and not only established a practical perspective to science at the Institute of Physical and Chemical Research but also worked vigorously to practice a science that went way beyond mere curiosity.
RIKEN is now a unique and mainstream scientific institute in Japan and this present position is indebted to the precious and determined efforts of Dr. Takamine and the other competent predecessors that followed. Now, with this great scientific heritage, BSI is taking another great leap forward.
A system is something that its constituent members should develop on their own. Yet, even when a system appears to be sufficiently robust, it may be more fragile than we expect. I do hope that RIKEN BSI will continue to develop competent human resources and thereby grow from just a source of cutting-edge research information, into an institute that is capable of scientific leadership on the world stage.
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