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Presenilin 1 Binding Proteins and Their Function

PS1 may act as a molecular tether, connecting GSK-3B with important substrates.


  1. Takashima, A., Murayama, M., Murayama, O., Kohno, T., Honda, T., Yasutake, K., Nihonmatsu, N., Mercken, M., Yamaguchi, H., Sugihara, S., Wolozin, B. Presenilin 1 associates with glycogen synthase kinase-3b and its substrate tau.
    Proc. Natl. Acad. Sci. USA. 95, 9637-9641(1998).

  2. Murayama, M., Tanaka, S., Palatino, J., Murayama, O., Honda, T., Nihonmatsu, N., Wolozin, B., Takashima, A. Direct association of presenilin-1 with b-catenin.
    FEBS lett. 433, 73-77(1998).

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