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Inhibition
Found to Be Essential for Brain Development
Laboratory for Neuronal
Circuit Development |
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Dr. Takao K. Hensch,
head of the Laboratory for Neuronal Circuit Development, announced for the first
time that the factor controlling a critical period for development of the visual
system was the inhibition of sensory signals. In the binocular region of visual
cortex (the area that first receives input from both eyes), neuronal circuits
are reorganized under the influence of visual experience only during a specific
period following birth (the so-called critical period). Importantly, large-scale
rewiring does not occur after the critical period. Using a mouse model whose inhibitory
transmission was genetically reduced, it was possible to observe circuit reorganization
even in adult animals once inhibition was pharmacologically restored. The normal
maturation of inhibitory interactions within the brain may allow proper coding
of sensory signals for plasticity to occur (cf. Fig.), but only once in life.
This revelation has established that inhibition is essential for plasticity of
neuronal circuits. The discovery is expected not only to provide new insight into
basic brain mechanisms, but also to contribute toward making transplanted tissues
function normally and understanding appropriate forms of stimulation for healthy
brain development in infants. |
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Inhibitory threshold for plasticity
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Fagiolini, M., Hensch, T. K. Inhibitory threshold for critical-period activation
in primary visual cortex Nature, 404, pp183-186, 9, March (2000)
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